| | |  | | | | Record from Web of Science® | | | | | | |
| REGULATORS OF CELL-DEATH |
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| Author(s): KORSMEYER SJ |
| Source: TRENDS IN GENETICS Volume: 11 Issue: 3 Pages: 101-105 Published: MAR 1995 |
| Times Cited: 519 References: 42 |
| Abstract: A novel oncogene-derived protein, Bcl-2, functions as a repressor of cell death in a genetic pathway of cellular suicide that appears to be common to all multicellular animals. A related protein that promotes cell death Bar, wrestles with Bcl-2 through conserved motifs, BH1 and BH2, establishing a set point for these deaths. In Bcl-2-deficient mice, the ratio of these molecules is reset, resulting in massive cell death in several cell types. |
| Document Type: Review |
| Language: English |
| Reprint Address: KORSMEYER, SJ (reprint author), WASHINGTON UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT MED & PATHOL, DIV MOLEC ONCOL, ST LOUIS, MO 63110 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Genetics & Heredity |
| IDS Number: QM647 |
| ISSN: 0168-9525 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |