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| HUMAN HERPESVIRUS-LIKE NUCLEIC-ACID IN VARIOUS FORMS OF KAPOSIS-SARCOMA |
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| Author(s): HUANG YQ, LI JJ, KAPLAN MH, POIESZ B, KATABIRA E, ZHANG WC, FEINER D, FRIEDMANKIEN AE |
| Source: LANCET Volume: 345 Issue: 8952 Pages: 759-761 Published: MAR 25 1995 |
| Times Cited: 379 References: 8 |
| Abstract: The association between a new human herpesvirus-like agent and various forms of Kaposi's sarcoma was examined by PCR. The DNA sequences of this agent were detected in 7 of 8 classic Kaposi's sarcoma specimens, 12 of 12 AIDS-associated specimens from the United States, and 7 of 10 specimens from African endemic Kaposi's sarcoma. Polymorphism of the herpesvirus-like DNA in the Kaposi's tissue from different populations was observed by both single-strand conformational polymorphism and direct sequencing. Furthermore, the presence and expression of the virus was detected in some Kaposi's tumours by Southern and northern blotting. This herpesvirus may be involved in the pathogenesis of different kinds of Kaposi's sarcoma seen among distinct and unrelated populations. |
| Document Type: Note |
| Language: English |
Addresses:
1. NYU, MED CTR, DEPT DERMATOL, NEW YORK, NY 10016 USA
2. NYU, MED CTR, DEPT MICROBIOL, NEW YORK, NY 10016 USA
3. N SHORE UNIV HOSP, DEPT MED, MANHASSET, NY USA
4. SUNY HLTH SCI CTR, CTR REG ONCOL, SYRACUSE, NY 13210 USA
5. MULAGO HOSP, DEPT MED, WHO, KAMPALA, UGANDA |
| Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL |
| Subject Category: Medicine, General & Internal |
| IDS Number: QN701 |
| ISSN: 0099-5355 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |