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| QUANTITATIVE-ANALYSIS OF DYNAMIC GD-DTPA ENHANCEMENT IN BREAST-TUMORS USING A PERMEABILITY MODEL |
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| Author(s): TOFTS PS, BERKOWITZ B, SCHNALL MD |
| Source: MAGNETIC RESONANCE IN MEDICINE Volume: 33 Issue: 4 Pages: 564-568 Published: APR 1995 |
| Times Cited: 197 References: 29 |
| Abstract: The MRI signal enhancement in a breast tumor, measured as a function of time after a bolus injection of Gd-DTPA, may contain enough information to differentiate malignant from benign tissue. We find a physiological model for measuring capillary permeability and leakage space (P. S. Tofts, A. G. Kermode, measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts. Magn. Reson. Med. 17, 357-367 (1991)) fits the data well. The enhancement curve is particularly sensitive to the preinjection T-1 of the tumor, the dose, and the time of injection. This model may provide a means of characterizing the pathophysiology of breast tumors from the Gd-DTPA enhancement curve. |
| Document Type: Note |
| Language: English |
Addresses:
1. UCL NATL HOSP NEUROL & NEUROSURG, INST NEUROL, NMR RES GRP, LONDON WC1N 3BG, ENGLAND
2. UNIV TEXAS, SW MED CTR, DEPT OPHTHALMOL & RADIOL, DALLAS, TX USA
3. UNIV PENN, MED CTR, DEPT RADIOL, PHILADELPHIA, PA 19104 USA |
| Publisher: WILLIAMS & WILKINS, 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 |
| Subject Category: Radiology, Nuclear Medicine & Medical Imaging |
| IDS Number: QP455 |
| ISSN: 0740-3194 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |