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| THE EXPRESSION OF THE HIGH-MOBILITY GROUP HMGI (Y) PROTEINS CORRELATES WITH THE MALIGNANT PHENOTYPE OF HUMAN THYROID NEOPLASIAS |
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| Author(s): CHIAPPETTA G, BANDIERA A, BERLINGIERI MT, VISCONTI R, MANFIOLETTI G, BATTISTA S, MARTINEZTELLO FJ, SANTORO M, GIANCOTTI V, FUSCO A |
| Source: ONCOGENE Volume: 10 Issue: 7 Pages: 1307-1314 Published: APR 6 1995 |
| Times Cited: 149 References: 34 |
| Abstract: High Mobility Group I(HMGI) proteins are nuclear proteins involved in the regulation of chromatin structure and function, Elevated expression of the HMGI proteins (HMGI, HMGY and HMGI-C) has been correlated with the presence of a highly malignant phenotype in epithelial and fibroblastic rat thyroid cells, and in several experimental carcinomas, Here, we demonstrate that HMGI and HMGY proteins are expressed in human thyroid carcinomas and thyroid carcinoma cell lines, but not in adenomas, goiters, normal thyroid tissues and cells, These results indicate a correlation between HMGI and HMGY expression and the malignant phenotype of thyroid neoplasias, suggesting that these proteins may be used as markers in thyroid cancer. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV REGGIO CALABRIA, FAC MED & CHIRURG, DIPARTIMENTO MED SPERIMENTALE & CLIN, I-88100 CATANZARO, ITALY
2. IST NAZL TUMORI, FDN SENATORE PASCALE, I-80131 NAPLES, ITALY
3. UNIV TRIESTE, DIPARTIMENTO BIOCHIM BIOFIS & CHIM MACROMOLEC, I-34127 TRIESTE, ITALY
4. UNIV NAPLES, FAC MED & CHIRURG, CNR, CTR ENDOCRINOL ONCOL SPERIMENTALE, I-80131 NAPLES, ITALY
5. UNIV COMPLUTENSE MADRID, HOSP UNIV 12 OCTUBRE, DEPT PATHOL, E-28041 MADRID, SPAIN |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HANTS, ENGLAND RG21 2XS |
| Subject Category: Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| IDS Number: QR651 |
| ISSN: 0950-9232 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |