| CREB AS A MEMORY MODULATOR - INDUCED EXPRESSION OF A DCREB2 ACTIVATOR ISOFORM ENHANCES LONG-TERM-MEMORY IN DROSOPHILA |
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| Author(s): YIN JCP, DELVECCHIO M, ZHOU H, TULLY T |
| Source: CELL Volume: 81 Issue: 1 Pages: 107-115 Published: APR 7 1995 |
| Times Cited: 368 References: 67 |
| Abstract: Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB). Here, we report an enhancement of LTM formation after induced expression of an activator isoform of dCREB2. Maximum LTM is achieved after one training session, and its formation depends on phosphorylation of the activator transgene. A model of LTM formation based on differential regulation of CREB isoforms is proposed. |
| Document Type: Article |
| Language: English |
| Reprint Address: YIN, JCP (reprint author), COLD SPRING HARBOR LAB, 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA |
| Publisher: CELL PRESS, 50 CHURCH ST CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: QR970 |
| ISSN: 0092-8674 |