| KILLING OF TRYPANOSOMES BY THE HUMAN HAPTOGLOBIN-RELATED PROTEIN |
|
|
| Author(s): SMITH AB, ESKO JD, HAJDUK SL |
| Source: SCIENCE Volume: 268 Issue: 5208 Pages: 284-286 Published: APR 14 1995 |
| Times Cited: 104 References: 21 |
| Abstract: African trypanosomes cause disease in humans and animals. Trypanosoma brucei brucei affects cattle but not humans because of its sensitivity to a subclass of human high density lipoproteins (HDLs) called trypanosome lytic factor (TLF). TLF contains two apolipoproteins that are sufficient to cause lysis of T. b. brucei in vitro. These proteins were identified as the human haptoglobin-related protein and paraoxonase-arylesterase. An antibody to haptoglobin inhibited TLF activity. TLF was shown to exhibit peroxidase activity and to be inhibited by catalase. These results suggest that TLF kills trypanosomes by oxidative damage initiated by its peroxidase activity. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV ALABAMA, SCH MED & DENT, DEPT BIOCHEM & MOLEC GENET, BIRMINGHAM, AL 35294 USA |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: QT185 |
| ISSN: 0036-8075 |