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| IMMUNIZATION BY DIRECT DNA INOCULATION INDUCES REJECTION OF TUMOR-CELL CHALLENGE |
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| Author(s): WANG B, MERVA M, DANG KS, UGEN KE, WILLIAMS WV, WEINER DB |
| Source: HUMAN GENE THERAPY Volume: 6 Issue: 4 Pages: 407-418 Published: APR 1995 |
| Times Cited: 46 References: 31 |
| Abstract: Direct DNA inoculation is the basis for a new technology that has been successfully used for in vivo induction of both humoral and cellular immune responses. However, the immunological parameters of this new approach remain to be evaluated in detail. We report here that direct DNA inoculation can induce protection from malignant tumor cell challenge through the generation of specific immune responses directed against antigens displayed on the tumor cells. The protected mice remain tumor-free for more than 1 year post-challenge. Memory responses upon tumor rechallenge were observed for both humoral and cellular immunity. Inoculated animals were able to reject otherwise lethal tumors several months following the original DNA inoculation protocol. These in vivo protective responses suggest that further analysis of this technology for vaccine development or immune therapeutic strategies is warranted. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USA
2. UNIV PENN, SCH MED, DEPT MED, DIV RHEUMATOL, PHILADELPHIA, PA 19104 USA
3. UNIV PENN, SCH MED, INST BIOTECHNOL & ADV MOLEC MED, PHILADELPHIA, PA 19104 USA
4. CHILDRENS HOSP, PHILADELPHIA, PA 19104 USA |
| Publisher: MARY ANN LIEBERT INC PUBL, 2 MADISON AVENUE, LARCHMONT, NY 10538 |
| Subject Category: Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental |
| IDS Number: QU204 |
| ISSN: 1043-0342 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |