| | |  | | | | Record from Web of Science® | | | | | | |
| MULTIPOINT INTERVAL MAPPING OF QUANTITATIVE TRAIT LOCI, USING SIB PAIRS |
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| Author(s): FULKER DW, CHERNY SS, CARDON LR |
| Source: AMERICAN JOURNAL OF HUMAN GENETICS Volume: 56 Issue: 5 Pages: 1224-1233 Published: MAY 1995 |
| Times Cited: 150 References: 14 |
| Abstract: The sib-pair interval-mapping procedure of Fulker and Cardon is extended to take account of all available marker information on a chromosome simultaneously. The method provides a computationally fast multipoint analysis of sib-pair data, using a modified Haseman-Elston approach. It gives results very similar to those of the earlier interval-mapping procedure when marker information is relatively uniform and a coarse map is used. However, there is a substantial improvement over the original method when markers differ in information content and/or when a dense map is employed. The method is illustrated by using simulated sib-pair data. |
| Document Type: Article |
| Language: English |
| Reprint Address: FULKER, DW (reprint author), UNIV COLORADO, INST BEHAV GENET, BOX 447, BOULDER, CO 80309 USA |
Addresses:
1. STANFORD UNIV, DEPT MATH, STANFORD, CA 94305 USA
2. SRI INT, HLTH SCI SECT, MENLO PK, CA 94025 USA |
| Publisher: UNIV CHICAGO PRESS, 5720 S WOODLAWN AVE, CHICAGO, IL 60637 |
| Subject Category: Genetics & Heredity |
| IDS Number: QU586 |
| ISSN: 0002-9297 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |