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| THE DCC GENE SUPPRESSES THE MALIGNANT PHENOTYPE OF TRANSFORMED HUMAN EPITHELIAL-CELLS |
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| Author(s): KLINGELHUTZ AJ, HEDRICK L, CHO KR, MCDOUGALL JK |
| Source: ONCOGENE Volume: 10 Issue: 8 Pages: 1581-1586 Published: APR 20 1995 |
| Times Cited: 77 References: 44 |
| Abstract: Loss of heterozygosity and loss of expression of the deleted in colon cancer (DCC) gene is frequently observed in a number of different cancer types. To determine if the DCC gene plays a direct role in tumor suppression, wild-type full-length or truncated DCC cDNA constructs were transfected into nitrosomethylurea (NMU) transformed tumorigenic HPV-immortalized human epithelial cells that had allelic loss and reduced expression of DCC. Full-length DCC suppressed tumorigenicity whereas truncated DCC did not. Tumorigenic reversion of initially suppressed transfectants was associated,vith loss of DCC expression and loss or rearrangement of transfected DCC sequences. These results provide the first direct evidence that DCC is a tumor suppressor gene. |
| Document Type: Article |
| Language: English |
| Reprint Address: KLINGELHUTZ, AJ (reprint author), FRED HUTCHINSON CANC RES CTR, CANC BIOL PROGRAM, 1124 COLUMBIA ST, SEATTLE, WA 98104 USA |
Addresses:
1. JOHNS HOPKINS UNIV, DEPT PATHOL, BALTIMORE, MD 21205 USA |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HANTS, ENGLAND RG21 2XS |
| Subject Category: Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| IDS Number: QU681 |
| ISSN: 0950-9232 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |