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| PROGRAMMED CELL-DEATH AND BCL-2 PROTECTION IN VERY-LOW OXYGEN |
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| Author(s): JACOBSON MD, RAFF MC |
| Source: NATURE Volume: 374 Issue: 6525 Pages: 814-816 Published: APR 27 1995 |
| Times Cited: 569 References: 29 |
| Abstract: PROGRAMMED cell death (PCD) is a fundamental feature of animal cells', but the mechanism remains unknown, Similarly, the Bcl-2 oncoprotein can suppress PCD in a variety of cell types and circumstances(2), but it is not known how it does so, It has been suggested that PCD involves the generation of reactive oxygen species (ROS) and that Bcl-2 protects against PCD by inhibiting the generation or action of ROS(3-6). To determine whether ROS are required for PCD, we cultured cells in a near-anaerobic atmosphere where the generation of ROS would be expected not to occur, or at least to be greatly reduced, We find that these conditions inhibit PCD induced by ROS-generating agents but do not inhibit PCD induced by other means, Furthermore, we show that Bcl-2 can protect cells from PCD in these anaerobic conditions. These results suggest that ROS are not required for PCD, and that Bcl-2 protects against PCD in ways that do not depend on the inhibition of ROS production or activity. |
| Document Type: Article |
| Language: English |
| Reprint Address: JACOBSON, MD (reprint author), UNIV LONDON UNIV COLL, MRC, DEV NEUROBIOL PROGRAMME, TORRINGTON PL, LONDON WC1E 6BT, ENGLAND |
Addresses:
1. UNIV LONDON UNIV COLL, MRC, MOLEC CELL BIOL LAB, LONDON WC1E 6BT, ENGLAND
2. UNIV LONDON UNIV COLL, DEPT BIOL, LONDON WC1E 6BT, ENGLAND |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: QV315 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |