| | |  | | | | Record from Web of Science® | | | | | | |
| POTENTIATED NECROSIS OF CULTURED CORTICAL-NEURONS BY NEUROTROPHINS |
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| Author(s): KOH JY, GWAG BJ, LOBNER D, CHOI DW |
| Source: SCIENCE Volume: 268 Issue: 5210 Pages: 573-575 Published: APR 28 1995 |
| Times Cited: 277 References: 42 |
| Abstract: The effects of neurotrophins on several forms of neuronal degeneration in murine cortical cell cultures were examined. Consistent with other studies, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 all attenuated the apoptotic death induced by serum deprivation or exposure lo the calcium channel antagonist nimodipine, Unexpectedly, however, 24-hour pretreatment with these same neurotrophins markedly potentiated the necrotic death induced by exposure to oxygen-glucose deprivation or N-methyl-D-aspartate. Thus, certain neurotrophins may have opposing effects on different types of death in the same neurons. |
| Document Type: Article |
| Language: English |
Addresses:
1. WASHINGTON UNIV, SCH MED, CTR STUDY NERVOUS SYST INJURY, ST LOUIS, MO 63110 USA
2. WASHINGTON UNIV, SCH MED, DEPT NEUROL, ST LOUIS, MO 63110 USA |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: QV407 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |