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| NEUROLIGIN-1 - A SPLICE SITE-SPECIFIC LIGAND FOR BETA-NEUREXINS |
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| Author(s): ICHTCHENKO K, HATA Y, NGUYEN T, ULLRICH B, MISSLER M, MOOMAW C, SUDHOF TC |
| Source: CELL Volume: 81 Issue: 3 Pages: 435-443 Published: MAY 5 1995 |
| Times Cited: 266 References: 25 |
| Abstract: Neurexins are neuronal cell surface proteins with hundreds of isoforms generated by alternative splicing. Here we describe neuroligin 1, a neuronal cell surface protein that is enriched in synaptic plasma membranes and acts as a splice site-specific ligand for beta-neurexins. Neuroligin 1 binds to beta-neurexins only if they lack an insert in the alternatively spliced sequence of the G domain, but not if they contain an insert, The extracellular sequence of neuroligin 1 is composed of a catalytically inactive esterase domain homologous to acetylcholinesterase. In situ hybridization reveals that alternative splicing of neurexins at the site recognized by neuroligin 1 is highly regulated. These findings support a model whereby alternative splicing of neurexins creates a family of cell surface receptors that confers Interactive specificity onto their resident neurons. |
| Document Type: Article |
| Language: English |
| Reprint Address: ICHTCHENKO, K (reprint author), UNIV TEXAS, SW MED CTR, DEPT MOLEC GENET, DALLAS, TX 75235 USA |
Addresses:
1. UNIV TEXAS, SW MED CTR, HOWARD HUGHES MED INST, DALLAS, TX 75235 USA |
| Publisher: CELL PRESS, 50 CHURCH ST CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: QW894 |
| ISSN: 0092-8674 |
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