| | |  | | | | Record from Web of Science® | | | | | | |
| RELOCATION OF THE CARBOXYTERMINAL PART OF CAN FROM THE NUCLEAR-ENVELOPE TO THE NUCLEUS AS A RESULT OF LEUKEMIA-SPECIFIC CHROMOSOME REARRANGEMENTS |
|
|
| Author(s): FORNEROD M, BOER J, VANBAAL S, JAEGLE M, VONLINDERN M, MURTI KG, DAVIS D, BONTEN J, BUIJS A, GROSVELD G |
| Source: ONCOGENE Volume: 10 Issue: 9 Pages: 1739-1748 Published: MAY 4 1995 |
| Times Cited: 106 References: 41 |
| Abstract: Fusion genes encoding the 3' part of the can gene are implicated in two types of leukemia, The dek-can fusion gene is present in t(6;9) acute myeloid leukemia and the set-can fusion gene is present in one case of acute undifferentiated leukemia. In order to obtain leads towards the molecular basis of these diseases, we have studied the cellular localization of the DEK-CAN and SET-CAN fusion proteins and their normal counterparts. DEK-CAN and SET-CAN were localized exclusively in the nucleus, and also DEK and SET were found to be nuclear proteins. However, CAN was mainly located at the nuclear and cytoplasmic face of the nuclear envelope. This observation is in accordance with the presence of an amino acid repeat in the C-terminal part of CAN, common to the family of nucleoporins. The C-terminal part also contains a nuclear location domain as shown by deletion analysis. This domain may be important for the presence of CAN at the nucleoplasmic side of the nuclear envelope. The relocation of the carboxyterminal part of CAN due to DEK-CAN and SET-CAN may reinforce a nuclear function of the CAN protein. |
| Document Type: Article |
| Language: English |
Addresses:
1. ST JUDE CHILDRENS HOSP, DEPT GENET, MEMPHIS, TN 38105 USA
2. ST JUDE CHILDRENS HOSP, DEPT VIROL & MOLEC BIOL, MEMPHIS, TN 38105 USA
3. ERASMUS UNIV ROTTERDAM, DEPT CELL BIOL & GENET, 3000 DR ROTTERDAM, NETHERLANDS
4. RES INST MOLEC PATHOL, A-1030 VIENNA, AUSTRIA |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HANTS, ENGLAND RG21 2XS |
| Subject Category: Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| IDS Number: QX469 |
| ISSN: 0950-9232 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |