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| THE PATERNAL INHERITANCE OF THE CENTROSOME, THE CELLS MICROTUBULE-ORGANIZING CENTER, IN HUMANS, AND THE IMPLICATIONS FOR INFERTILITY |
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| Author(s): SIMERLY C, WU GJ, ZORAN S, ORD T, RAWLINS R, JONES J, NAVARA C, GERRITY M, RINEHART J, BINOR Z, ASCH R, SCHATTEN G |
| Source: NATURE MEDICINE Volume: 1 Issue: 1 Pages: 47-52 Published: JAN 1995 |
| Times Cited: 161 References: 36 |
| Abstract: Successful fertilization in humans, achieved when parental chromosomes intermix at first mitosis, requires centrosome restoration and microtubule-mediated motility. Imaging of inseminated human oocytes reveals that the sperm introduces the centrosome. The centrosome then nucleates the new microtubule assembly to form the sperm aster - a step essential for successful fertilization. Oocytes from some infertile patients failed to complete fertilization because of defects in uniting the sperm and egg nuclei, indicating that failure to properly effect the cytoplasmic motions uniting the nuclei results in human infertility. These discoveries have important implications for infertility diagnosis and managing reproduction. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV WISCONSIN, DEPT ZOOL, MADISON, WI 53706 USA
2. UNIV WISCONSIN, WISCONSIN REG PRIMATE RES CTR, MADISON, WI 53706 USA
3. UNIV WISCONSIN, DEPT OBSTET & GYNECOL, MADISON, WI 53706 USA
4. UNIV CALIF IRVINE, IRVINE MED CTR, CTR REPROD HLTH, ORANGE, CA 92668 USA
5. RUSH UNIV, REPROD ENDOCRINOL & INFERTIL SECT, CHICAGO, IL 60612 USA
6. GLENBROOK HOSP, ASSISTED REPROD TECHNOL PROGRAM, GLENVIEW, IL 60025 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: QX557 |
| ISSN: 1078-8956 |
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