| | |  | | | | Record from Web of Science® | | | | | | |
| THE ANTIDEPRESSANT ROLIPRAM SUPPRESSES CYTOKINE PRODUCTION AND PREVENTS AUTOIMMUNE ENCEPHALOMYELITIS |
|
|
| Author(s): SOMMER N, LOSCHMANN PA, NORTHOFF GH, WELLER M, STEINBRECHER A, STEINBACH JP, LICHTENFELS R, MEYERMANN R, RIETHMULLER A, FONTANA A, DICHGANS J, MARTIN R |
| Source: NATURE MEDICINE Volume: 1 Issue: 3 Pages: 244-248 Published: MAR 1995 |
| Times Cited: 236 References: 36 |
| Abstract: In multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) the cytokines tumour necrosis factor-alpha (TNF), lymphotoxin-alpha (LT), and interferon-gamma (IFN-gamma) are of central pathogenetic importance. A therapy capable of stopping neurological deterioration in MS patients is not yet available. Here, we report that rolipram, a selective type IV phosphodiesterase inhibitor, stereospecifically suppresses the production of TNF/LT and less strongly also IFN-gamma in human and rat autoreactive T cells. Moreover, we show that rolipram is an effective treatment for EAE. Rolipram has extensively been studied in humans for the treatment of depression, but has not yet been marketed. The data presented here identify rolipram as potential therapy for multiple sclerosis and provoke the immediate initiation of clinical trials. |
| Document Type: Article |
| Language: English |
| Reprint Address: SOMMER, N (reprint author), UNIV TUBINGEN, DEPT NEUROL, HOPPE SEYLER STR 3, D-72076 TUBINGEN, GERMANY |
Addresses:
1. UNIV TUBINGEN, DEPT TRANSFUS MED, D-72076 TUBINGEN, GERMANY
2. UNIV ZURICH HOSP, DEPT INTERNAL MED, CLIN IMMUNOL SECT, CH-8044 ZURICH, SWITZERLAND
3. UNIV TUBINGEN, INST BRAIN RES, D-72076 TUBINGEN, GERMANY
4. NINCDS, NEUROIMMUNOL BRANCH, BETHESDA, MD 20892 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: QX559 |
| ISSN: 1078-8956 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |