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| EVIDENCE FOR A SUSCEPTIBILITY LOCUS FOR SCHIZOPHRENIA ON CHROMOSOME 6PTER-P22 |
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| Author(s): WANG SB, SUN CE, WALCZAK CA, ZIEGLE JS, KIPPS BR, GOLDIN LR, DIEHL SR |
| Source: NATURE GENETICS Volume: 10 Issue: 1 Pages: 41-46 Published: MAY 1995 |
| Times Cited: 205 References: 44 |
| Abstract: We have performed linkage analysis in 186 multiplex families to search for genes that predispose to schizophrenia. Under a model with partially dominant inheritance, moderately broad disease definition and assuming locus homogeneity, a lod score of 3.2 was obtained for D6S260 on chromosome 6p23. A multipoint lod score of 3.9 (P=2.3 x 10(-5)) was achieved when the F13A1 and D6S260 loci were analysed, allowing for locus heterogeneity. Adjusted for testing of multiple models, the multipoint lod score of 3.9 under heterogeneity has a genome wide significance of between 5-8%. The nonparametric affected pedigree member test provided. results (P=3 x 10(-4)) also supporting this finding. Our findings provide supportive evidence for a susceptibility locus for schizophrenia on distal chromosome 6p, and support a model of locus heterogeneity. |
| Document Type: Article |
| Language: English |
Addresses:
1. NIDR, MOLEC EPIDEMIOL & DIS INDICATORS BRANCH, BETHESDA, MD 20892 USA
2. NIMH, CLIN NEUROGENET BRANCH, BETHESDA, MD 20892 USA
3. PERKIN ELMER CORP, DIV APPL BIOSYST, FOSTER CITY, CA 94404 USA
4. VIRGINIA COMMONWEALTH UNIV, SCH DENT, CLIN PERIODONTAL DIS RES CTR, RICHMOND, VA 23298 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: QX573 |
| ISSN: 1061-4036 |
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