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| T-CELL-RECEPTOR REPERTOIRE IN CHRONIC PLAQUE-STAGE PSORIASIS IS RESTRICTED AND LACKS ENRICHMENT OF SUPERANTIGEN-ASSOCIATED V-BETA REGIONS |
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| Author(s): BOEHNCKE WH, DRESSEL D, MANFRAS B, ZOLLNER TM, WETTSTEIN A, BOHM BO, STERRY W |
| Source: JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 104 Issue: 5 Pages: 725-728 Published: MAY 1995 |
| Times Cited: 33 References: 20 |
| Abstract: Preferential usage of certain T-cell receptors by the lymphocytic infiltrate in psoriasis might indicate the involvement of an antigen in the pathogenesis of this disease. However, to date there are no data on the complete T-cell-receptor V alpha and V beta repertoire in psoriatic patients, We therefore compared the usage of T-cell-receptor variable regions in blood and skin of 10 patients with chronic plaque-stage psoriasis by means of semiquantitative polymerase chain reaction, Additionally, HLA class II alleles were analyzed by means of sequence-specific oligonucleotide typing. A considerable restriction of the T-cell-receptor repertoire was observed in the skin, where up to 20% of the variable regions present in the blood were not detectable, This was true for both alpha- and beta-chains, However, no interindividually constant pattern of T-cell-receptor restriction was deducible, Inconsistently, a certain preferential usage of some beta chains occurred within the cutaneous compartment. This report on the complete T-cell-receptor V alpha and V beta repertoire in psoriasis documents the restricted receptor repertoire of infiltrating T cells and a lack of enrichment of superantigen-associated V beta regions, Thus superantigens seem not to play a pathogenetically relevant role in chronic plaque-stage psoriasis. |
| Document Type: Article |
| Language: English |
| Reprint Address: BOEHNCKE, WH (reprint author), UNIV ULM, DEPT DERMATOL, OBERER ESELSBERG 40, D-89081 ULM, GERMANY |
Addresses:
1. UNIV ULM, DEPT ENDOCRINOL, D-89081 ULM, GERMANY |
| Publisher: BLACKWELL SCIENCE PUBL INC CAMBRIDGE, 238 MAIN ST, CAMBRIDGE, MA 02142 |
| Subject Category: Dermatology |
| IDS Number: QX926 |
| ISSN: 0022-202X |
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