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| IMMUNOHISTOCHEMICAL EVALUATION OF E-CADHERIN AND EPIDERMAL GROWTH-FACTOR RECEPTOR IN NONSMALL CELL LUNG-CANCER |
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| Author(s): SORSCHER SM, RUSSACK V, GRAZIANO S, CAGLE M, FERAMISCO JR, GREEN MR |
| Source: MODERN PATHOLOGY Volume: 8 Issue: 4 Pages: 450-455 Published: MAY 1995 |
| Times Cited: 13 References: 43 |
| Abstract: Enhanced expression of the epidermal growth factor receptor and loss of expression of the cell-cell adhesion molecule E-cadherin have each been implicated in the development and progression of a variety of human malignancies. There is some evidence for a correlation between the expression of these two genes and the possible influence of the E-cadherin gene product on the expression of epidermal growth factor receptor. We evaluated 33 matched primary and metastatic non-small cell lung cancer specimens using immunohistochemical staining. There was a statistically significant correlation between staining intensity for epidermal growth factor receptor and E-cadherin in the primary tumors (P = 0.017, by Spearman correlation test). No difference was noted between primary and metastatic disease for either gene product. Studies that include clinical data are needed to clarify the significance of these findings and to evaluate whether these markers will help predict prognosis in tumors. |
| Document Type: Article |
| Language: English |
| Reprint Address: SORSCHER, SM (reprint author), UNIV CALIF SAN DIEGO, CTR CANC, 9500 GILMAN DR 0636, LA JOLLA, CA 92093 USA |
Addresses:
1. UNIV CALIF SAN DIEGO, DEPT MED, LA JOLLA, CA 92093 USA
2. UNIV CALIF SAN DIEGO, DEPT PATHOL, LA JOLLA, CA 92093 USA
3. SUNY SYRACUSE, HLTH SCI CTR, DEPT MED, SYRACUSE, NY 13210 USA
4. VET ADM MED CTR, SYRACUSE, NY 13210 USA |
| Publisher: WILLIAMS & WILKINS, 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 |
| Subject Category: Pathology |
| IDS Number: QZ098 |
| ISSN: 0893-3952 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |