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| PROTECTION BY ATTENUATED SIMIAN IMMUNODEFICIENCY VIRUS IN MACAQUES AGAINST CHALLENGE WITH VIRUS-INFECTED CELLS |
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| Author(s): ALMOND N, KENT K, CRANAGE M, RUD E, CLARKE B, STOTT EJ |
| Source: LANCET Volume: 345 Issue: 8961 Pages: 1342-1344 Published: MAY 27 1995 |
| Times Cited: 179 References: 10 |
| Abstract: A vaccine against AIDS will probably have to protect against challenge both by viable virus-infected cells and by cell-free virus. Eight cynomolgus macaques infected with attenuated simian immunodeficiency virus (SIV) were challenged (four each) with cell-free and cell-associated SIV, All were protected, whereas eight controls were all infected after challenge. These findings show that live-attenuated vaccine can confer protection against SIV in macaques, Extrapolation to human beings will require extensive evaluation of the safety of attenuated retroviruses. Alternatively, the mechanism of this potent protection must be understood and reproduced by less hazardous means. |
| Document Type: Note |
| Language: English |
| Reprint Address: ALMOND, N (reprint author), NATL INST BIOL STAND & CONTROLS, BLANCHE LANE S MIMMS, POTTERS BAR EN6 3QG, HERTS ENGLAND |
Addresses:
1. CTR APPL MICROBIOL & RES, SALISBURY, WILTS ENGLAND
2. WELLCOME RES LABS, BECKENHAM BR3 3BS, KENT ENGLAND
3. HLTH CANADA, LAB CTR DIS CONTROL, BUR HIV AIDS, OTTAWA, ON CANADA |
| Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL |
| Subject Category: Medicine, General & Internal |
| IDS Number: RA148 |
| ISSN: 0099-5355 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |