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| INACTIVATION OF THE TYPE-II TGF-BETA RECEPTOR IN COLON-CANCER CELLS WITH MICROSATELLITE INSTABILITY |
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| Author(s): MARKOWITZ S, WANG J, MYEROFF L, PARSONS R, SUN LZ, LUTTERBAUGH J, FAN RS, ZBOROWSKA E, KINZLER KW, VOGELSTEIN B, BRATTAIN M, WILLSON JKV |
| Source: SCIENCE Volume: 268 Issue: 5215 Pages: 1336-1338 Published: JUN 2 1995 |
| Times Cited: 1,612 References: 36 |
| Abstract: Transforming growth factor-beta (TGF-beta) is a potent inhibitor of epithelial cell growth. Human colon cancer cell lines with high rates of microsatellite instability were found to harbor mutations in the type II TGF-beta receptor (RII) gene. Eight such examples, due to three different mutations, were identified. The mutations were clustered within small repeated sequences in the RII gene, were accompanied by the absence of cell surface RII receptors, and were usually associated with small amounts of RII transcript. RII mutation, by inducing the escape of cells from TGF-beta-mediated growth control, links DNA repair defects with a specific pathway of tumor progression. |
| Document Type: Article |
| Language: English |
| Reprint Address: MARKOWITZ, S (reprint author), UNIV CLEVELAND HOSP, DEPT MED, ROOM 200, 11001 CEDAR RD, CLEVELAND, OH 44106 USA |
Addresses:
1. UNIV CLEVELAND HOSP, IRELAND CANC CTR, CLEVELAND, OH 44106 USA
2. CASE WESTERN RESERVE UNIV, CLEVELAND, OH 44106 USA
3. MED COLL OHIO, DEPT BIOCHEM & MOLEC BIOL, TOLEDO, OH 43699 USA
4. JOHNS HOPKINS UNIV, CTR ONCOL, BALTIMORE, MD 21231 USA
5. HOWARD HUGHES MED INST, CHEVY CHASE, MD 20815 USA |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: RB198 |
| ISSN: 0036-8075 |
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