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| EFFECT OF HUPERZINE-A, A NOVEL ACETYLCHOLINESTERASE INHIBITOR, ON RADIAL MAZE PERFORMANCE IN RATS |
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| Author(s): XIONG ZQ, TANG XC |
| Source: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR Volume: 51 Issue: 2-3 Pages: 415-419 Published: JUN-JUL 1995 |
| Times Cited: 24 References: 24 |
| Abstract: Rats were trained to run in a spatial, radial arm maze using a procedure to determine two memory functions, working and reference memory. The muscarinic antagonist, not the nicotinic antagonist, impaired both working and reference memory of rats. Scopolamine (0.125, 0.15, and 0.2 mg/kg, IP, 30 min before a session) significantly impaired choice accuracy in the eight-arm maze. In contrast, mecamylamine (5, 10, and 15 mg/kg) did not affect the performance. Huperzine A (0.1, 0.2, and 0.3 mg/kg, IF, 30 min before testing) and physostigmine (0.3 mg/kg, IF, 20 min before testing) could reverse scopolamine-induced deficits in the task. Chronic treatment with huperzine A (0.25 mg/kg, PO, once a day) for 8 consecutive days was as potent as acute treatment on attenuating the scopolamine-induced amnesia. |
| Document Type: Article |
| Language: English |
Addresses:
1. CHINESE ACAD SCI, SHANGHAI INST MAT MED, DEPT PHARMACOL, SHANGHAI 200031, PEOPLES R CHINA |
| Publisher: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB |
| Subject Category: Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy |
| IDS Number: RB491 |
| ISSN: 0091-3057 |
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