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| EXPRESSION OF PROSTAGLANDIN G/H SYNTHASE-1 AND SYNTHASE-2 PROTEIN IN HUMAN COLON-CANCER |
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| Author(s): KARGMAN SL, ONEILL GP, VICKERS PJ, EVANS JF, MANCINI JA, JOTHY S |
| Source: CANCER RESEARCH Volume: 55 Issue: 12 Pages: 2556-2559 Published: JUN 15 1995 |
| Times Cited: 654 References: 24 |
| Abstract: Prostaglandin G/H synthase (PGHS), a key enzyme leading to the formation of prostaglandins, is the target of nonsteroidal antiinflammatory drugs. Two forms of the enzyme have been identified, PGHS-1 and PGHS-2. Epidemiological evidence has suggested that aspirin and other nonsteroidal antiinflammatory drugs may reduce the risk of colorectal cancer. We examined by immunoblot analyses the expression of human PGHS-1 and PGHS-2 protein in 25 matched colon cancer and nontumor tissues, 4 premalignant polyps, 5 control colon tissues from noncancer patients, and 3 matched normal and cancerous breast tissue samples. PGHS-1 was detected in all normal and tumor tissue. In contrast, PGHS-2 was not detected in 23 of 25 normal colon tissues but was detected in 19 of 25 colon tumors. PGHS-2 protein was not observed in four human premalignant polyp samples, control colon from noncancer patients, or matched normal or cancerous breast tissues. These results suggest that the beneficial effects of nonsteroidal antiinflammatory drugs in colon cancer may be mediated by inhibition of PGHS-2. |
| Document Type: Article |
| Language: English |
| Reprint Address: KARGMAN, SL (reprint author), MERCK FROSST CTR THERAPEUT RES, DEPT BIOCHEM & MOLEC BIOL, POB 1005, POINTE CLAIRE, PQ H9R 4P8 CANADA |
Addresses:
1. PFIZER LTD, CENT RES, DEPT MOLEC SCI, SANDWICH CT13 9NJ, KENT ENGLAND
2. MCGILL UNIV, DEPT PATHOL, MONTREAL, PQ H3A 2B4 CANADA |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: RC936 |
| ISSN: 0008-5472 |
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