| | |  | | | | Record from Web of Science® | | | | | | |
| AN EXCITATORY AMINO-ACID TRANSPORTER WITH PROPERTIES OF A LIGAND-GATED CHLORIDE CHANNEL |
|
|
| Author(s): FAIRMAN WA, VANDENBERG RJ, ARRIZA JL, KAVANAUGH MP, AMARA SG |
| Source: NATURE Volume: 375 Issue: 6532 Pages: 599-603 Published: JUN 15 1995 |
| Times Cited: 710 References: 30 |
| Abstract: EXCITATORY amino-acid transporters (EAATs) in the central nervous system maintain extracellular glutamate concentrations below excitotoxic levels and may limit the activation of glutamate receptors. Here we report the cloning of a novel human aspartate/glutamate transporter, EAAT4, which is expressed predominantly in the cerebellum. The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, and has a pharmacological profile consistent with previously described cerebellar transport activities. In Xenopus oocytes expressing EAAT4, L-aspartate and L-glutamate elicited a current predominantly carried by chloride ions. This chloride conductance was not blocked by components that block endogenous oocyte chloride channels. Thus EAAT4 combines the re-uptake of neurotransmitter with a mechanism for increasing chloride permeability, both of which could regulate excitatory neurotransmission. |
| Document Type: Article |
| Language: English |
Addresses:
1. OREGON HLTH SCI UNIV, HOWARD HUGHES MED INST, PORTLAND, OR 97201 USA
2. OREGON HLTH SCI UNIV, VOLLUM INST ADV BIOMED RES, PORTLAND, OR 97201 USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: RD287 |
| ISSN: 0028-0836 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |