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| INCIDENCE OF CONGENITAL HEART-DISEASE .2. PRENATAL INCIDENCE |
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| Author(s): HOFFMAN JIE |
| Source: PEDIATRIC CARDIOLOGY Volume: 16 Issue: 4 Pages: 155-165 Published: JUL-AUG 1995 |
| Times Cited: 111 References: 79 |
| Abstract: The incidence of congenital heart disease appears to be about 1 per 100 liveborn infants. In infants who die before term, however, there is a much higher incidence of congenital heart disease, with a tendency for an excess of complex lesions. Some but not all of these lesions are associated with gross chromosomal abnormalities, which occur frequently in first-trimester abortions. Most of these chromosomal abnormalities are associated with such maldevelopment of many organ systems that fetal death occurs in utero. Monosomy X (45, XO), has a high association with congenital heart disease. Most fetuses with this abnormality die in utero, but because the abnormality is not inevitably lethal a small increase in survival of these fetuses would cause a large increase in the total incidence of congenital heart disease. |
| Document Type: Article |
| Language: English |
| Reprint Address: HOFFMAN, JIE (reprint author), UNIV CALIF SAN FRANCISCO, DEPT PEDIAT, BOX 0544, HSE 1403, SAN FRANCISCO, CA 94143 USA |
Addresses:
1. UNIV CALIF SAN FRANCISCO, INST CARDIOVASC RES, SAN FRANCISCO, CA 94143 USA |
| Publisher: SPRINGER VERLAG, 175 FIFTH AVE, NEW YORK, NY 10010 |
| Subject Category: Cardiac & Cardiovascular Systems; Pediatrics |
| IDS Number: RE266 |
| ISSN: 0172-0643 |
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