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| PROGESTERONE FAVORS THE DEVELOPMENT OF HUMAN T-HELPER CELLS PRODUCING TH2-TYPE CYTOKINES AND PROMOTES BOTH IL-4 PRODUCTION AND MEMBRANE CD30 EXPRESSION IN ESTABLISHED TH1 CELL CLONES |
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| Author(s): PICCINNI MP, GIUDIZI MG, BIAGIOTTI R, BELONI L, GIANNARINI L, SAMPOGNARO S, PARRONCHI P, MANETTI R, ANNUNZIATO F, LIVI C, ROMAGNANI S, MAGGI E |
| Source: JOURNAL OF IMMUNOLOGY Volume: 155 Issue: 1 Pages: 128-133 Published: JUL 1 1995 |
| Times Cited: 366 References: 31 |
| Abstract: The effect of progesterone (P) on the cytokine production profile of Ag-specific human CD4(+) T cell lines and clones was investigated. T cell lines specific for purified protein derivative or streptokinase (SK) derived in the presence of P exhibited significant increased ability to produce IL-5 in comparison with T cell lines derived in the absence of P. Moreover, IL-4 was significantly increased in SK-specific T cell lines derived in the presence of P in comparison with SK-specific T cell lines derived in the absence of this hormone. In addition, SK-specific T cell lines generated in the presence of P developed into T cell clones showing a Th0-, instead of Th1-like, cytokine profile. Furthermore, SK-specific T cell clones with an established Th1 profile of cytokine secretion did express mRNA for, and produced detectable amounts of, IL-4 when stimulated with P in combination with insoluble anti-CD3 mAb. Combined stimulation with P and insoluble anti-CD3 mAb also enabled Th1 clones to express CD30 on their surface membrane. These results indicate that P can favor the development of Th cells producing Th2-type cytokines and is an inducer of both transient IL-4 production and CD30 expression in established Th1 cells. Thus, P production at the placental level may be responsible, al least in part, for increased production of Th2-type cytokines which have been implied in fetal allograft survival and maintenance of successful pregnancy. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV FLORENCE, DIV CLIN IMMUNOL & ALLERGY, FLORENCE, ITALY
2. UNIV FLORENCE, INST OBSTET & GYNAECOL, FLORENCE, ITALY |
| Publisher: AMER ASSOC IMMUNOLOGISTS, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 |
| Subject Category: Immunology |
| IDS Number: RE574 |
| ISSN: 0022-1767 |
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