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THE SYNAPTIC VESICLE CYCLE - A CASCADE OF PROTEIN-PROTEIN INTERACTIONS
Author(s): SUDHOF TC
Source: NATURE    Volume: 375    Issue: 6533    Pages: 645-653    Published: JUN 22 1995  
Times Cited: 1,539     References: 119     
Abstract: The synaptic vesicle cycle at the nerve terminal consists of vesicle exocytosis with neurotransmitter release, endocytosis of empty vesicles, and regeneration of fresh vesicles. Of all cellular transport pathways, the synaptic vesicle cycle is the fastest and the most tightly regulated. A convergence of results now allows formulation of molecular models for key steps of the cycle. These developments may form the basis for a mechanistic understanding of higher neural function.
Document Type: Review
Language: English
Reprint Address: SUDHOF, TC (reprint author), UNIV TEXAS, HLTH SCI CTR, SW MED SCH, DEPT MOLEC GENET, DALLAS, TX 75235 USA
Addresses:
1. UNIV TEXAS, HLTH SCI CTR, SW MED SCH, HOWARD HUGHES MED INST, DALLAS, TX 75235 USA
Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF
Subject Category: Multidisciplinary Sciences
IDS Number: RE576
ISSN: 0028-0836
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