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| HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) TYPE-1 INFECTION STATUS AND IN-VITRO SUSCEPTIBILITY TO HIV-INFECTION AMONG HIGH-RISK HIV-1 SERONEGATIVE HEMOPHILIACS |
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| Author(s): LEDERMAN MM, JACKSON JB, KRONER BL, WHITE GC, EYSTER ME, ALEDORT LM, HILGARTNER MW, KESSLER CM, COHEN AR, KIGER KP, GOEDERT JJ |
| Source: JOURNAL OF INFECTIOUS DISEASES Volume: 172 Issue: 1 Pages: 228-231 Published: JUL 1995 |
| Times Cited: 15 References: 15 |
| Abstract: Blood samples were obtained from 16 hemophiliacs who had a 50%-94% defined risk of human immunodeficiency virus (HIV type 1 infection on the basis of treatment history and from 14 controls not at risk for HIV infection. HIV-1 was not detected in any of 12 patient samples by cocultivation nor in 14 patient samples by the polymerase chain reaction. Peripheral blood cells from 7 seronegative hemophiliacs at highest risk of seroconversion (94%) were less susceptible to HIV-1 infection in vitro than were cells from healthy controls (P < .025, one-tailed Wilcoxon rank sum test). In contrast, the susceptibility to HIV-1 infection of lymphocytes from 6 seronegative hemophiliacs at moderate risk (50%-56%) of seroconversion did not differ from that of cells from controls or from high-risk hemophiliacs. Therefore, prolonged periods of seronegative HIV-1 infection are not common in this high-risk population. In addition, among hemophiliacs there may exist heterogeneity in susceptibility to HIV-1 infection in vitro and in vivo. |
| Document Type: Note |
| Language: English |
| Reprint Address: LEDERMAN, MM (reprint author), UNIV CLEVELAND HOSP, DIV INFECT DIS, 11100 EUCLID AVE, CLEVELAND, OH 44106 USA |
Addresses:
1. CASE WESTERN RESERVE UNIV, CLEVELAND, OH 44106 USA
2. RES TRIANGLE INST, ROCKVILLE, MD USA
3. NCI, VIRAL EPIDEMIOL BRANCH, BETHESDA, MD USA
4. UNIV N CAROLINA, CHAPEL HILL, NC USA
5. PENN STATE UNIV, SCH MED, HERSHEY, PA USA
6. UNIV PENN, SCH MED, PHILADELPHIA, PA 19104 USA
7. CHILDRENS HOSP, PHILADELPHIA, PA 19104 USA
8. CORNELL UNIV, SCH MED, NEW YORK, NY 10021 USA
9. MT SINAI SCH MED, NEW YORK, NY USA
10. GEORGE WASHINGTON UNIV, SCH MED, WASHINGTON, DC USA |
| Publisher: UNIV CHICAGO PRESS, 5720 S WOODLAWN AVE, CHICAGO, IL 60637 |
| Subject Category: Infectious Diseases |
| IDS Number: RF041 |
| ISSN: 0022-1899 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |