| | |  | | | | Record from Web of Science® | | | | | | |
| ALLELOTYPING OF FOLLICULAR THYROID-TUMORS |
|
|
| Author(s): ZEDENIUS J, WALLIN G, SVENSSON A, GRIMELIUS L, HOOG A, LUNDELL G, BACKDAHL M, LARSSON C |
| Source: HUMAN GENETICS Volume: 96 Issue: 1 Pages: 27-32 Published: JUL 1995 |
| Times Cited: 44 References: 35 |
| Abstract: To elucidate further the genetic mechanisms for follicular thyroid tumor development and progression, we allelotyped follicular thyroid tumors and other thyroid lesions from 92 patients. In general, a low frequency of loss of heterozygosity (LOH) was found, the highest being for chromosomes 3q, 10q, 11p, 11q, 13q, and 22q (10%-15%). However, detailed study of LOH of these chromosome arms with regard to the different histopathological diagnoses indicates that a locus on chromosome 10q may be involved in follicular thyroid tumor progression. In addition, the majority of Hurthle cell adenomas showed LOH on either chromosome 3q or 18q, in contrast to the other tumor types. This discrepancy in genetic alterations may contribute to the divergent clinical features occurring in these tumors. |
| Document Type: Article |
| Language: English |
| Reprint Address: ZEDENIUS, J (reprint author), KAROLINSKA HOSP, DEPT SURG, S-17176 STOCKHOLM, SWEDEN |
Addresses:
1. KAROLINSKA HOSP, DEPT MOLEC MED, ENDOCRINE TUMOR UNIT, S-17176 STOCKHOLM, SWEDEN
2. KAROLINSKA HOSP, DEPT PATHOL, S-17176 STOCKHOLM, SWEDEN
3. KAROLINSKA HOSP, DEPT ONCOL, S-17176 STOCKHOLM, SWEDEN
4. UNIV UPPSALA HOSP, DEPT PATHOL, S-75185 UPPSALA, SWEDEN |
| Publisher: SPRINGER VERLAG, 175 FIFTH AVE, NEW YORK, NY 10010 |
| Subject Category: Genetics & Heredity |
| IDS Number: RF379 |
| ISSN: 0340-6717 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |