| | |  | | | | Record from Web of Science® | | | | | | |
| P75 AND TRK - A 2-RECEPTOR SYSTEM |
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| Author(s): CHAO MV, HEMPSTEAD BL |
| Source: TRENDS IN NEUROSCIENCES Volume: 18 Issue: 7 Pages: 321-326 Published: JUL 1995 |
| Times Cited: 535 References: 61 |
| Abstract: The neurotrophin family of survival factors is distinguished by a unique receptor-signaling system that is composed of two transmembrane receptor proteins. Nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3 (NT-3) and NF-4/5 share similar protein structures and biological functions and interact with two different types of cell-surface proteins, the Trk family of receptor tyrosine kinases, and the p75, or low-affinity neurotrophin receptor. An important question is whether a dual receptor system is necessary for neurotrophin action. Evidence indicates that co-expression of the two genes for the p75 receptor and the Trk NGF receptor can potentially lead to greater responsiveness to NGF, and suggests additional levels of regulation for the family of neurotrophin factors. |
| Document Type: Review |
| Language: English |
| Reprint Address: CHAO, MV (reprint author), CORNELL UNIV, COLL MED, DEPT ANAT & CELL BIOL, DIV HEMATOL ONCOL, 1300 YORK AVE, NEW YORK, NY 10021 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Neurosciences |
| IDS Number: RF703 |
| ISSN: 0166-2236 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |