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| THE INTRAVASCULAR CONTRIBUTION TO FMRI SIGNAL CHANGE - MONTE-CARLO MODELING AND DIFFUSION-WEIGHTED STUDIES IN-VIVO |
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| Author(s): BOXERMAN JL, BANDETTINI PA, KWONG KK, BAKER JR, DAVIS TL, ROSEN BR, WEISSKOFF RM |
| Source: MAGNETIC RESONANCE IN MEDICINE Volume: 34 Issue: 1 Pages: 4-10 Published: JUL 1995 |
| Times Cited: 295 References: 38 |
| Abstract: Understanding the relationship between fMRI signal changes and activated cortex is paramount to successful mapping of neuronal activity. To this end, the relative extravascular and intravascular contribution to fMRI signal change from capillaries (localized), venules (less localized) and macrovessels (remote, draining veins) must be determined, In this work, the authors assessed both the extravascular and intravascular contribution to blood oxygenation level-dependent gradient echo signal change at 1.5 T by using a Monte Carlo model for susceptibility-based contrast in conjunction with a physiological model for neuronal activation-induced changes in oxygenation and vascular volume fraction, The authors compared our Model results with experimental fMRI signal changes with and without velocity sensitization via bipolar gradients to null the intravascular signal. The model and experimental results are in agreement and suggest that the intravascular spins account for the majority of fMRI signal change on T-2*-weighted images at 1.5 T. |
| Document Type: Article |
| Language: English |
| Reprint Address: BOXERMAN, JL (reprint author), MASSACHUSETTS GEN HOSP, CTR NMR, DEPT RADIOL, BLDG 149 2301, 13TH ST, BOSTON, MA 02129 USA |
Addresses:
1. HARVARD UNIV, SCH MED, CAMBRIDGE, MA 02138 USA
2. HARVARD MIT DIV HLTH SCI & TECHNOL, BOSTON, MA USA |
| Publisher: WILLIAMS & WILKINS, 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 |
| Subject Category: Radiology, Nuclear Medicine & Medical Imaging |
| IDS Number: RF768 |
| ISSN: 0740-3194 |
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