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| DIFFERENTIAL ROLE OF THE LOW-AFFINITY NEUROTROPHIN RECEPTOR (P75) IN RETROGRADE AXONAL-TRANSPORT OF THE NEUROTROPHINS |
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| Author(s): CURTIS R, ADRYAN KM, STARK JL, PARK JS, COMPTON DL, WESKAMP G, HUBER LJ, CHAO MV, JAENISCH R, LEE KF, LINDSAY RM, DISTEFANO PS |
| Source: NEURON Volume: 14 Issue: 6 Pages: 1201-1211 Published: JUN 1995 |
| Times Cited: 165 References: 63 |
| Abstract: The receptor mechanisms mediating the retrograde axonal transport of the neurotrophins have been investigated in adult rats. We show that transport of the TrkB ligands NT-4 and BDNF to peripheral neurons is dependent on the low affinity neurotrophin receptor (LNR). Pharmacological manipulation of LNR in vivo using either an anti-LNR antibody or a soluble recombinant LNR extracellular domain completely blocked retrograde transport of NT-4 and BDNF to sensory neurons, while having minimal effects on the transport of NGF in either sensory or sympathetic, neurons. Furthermore, in mice with a null mutation of LNR, the transport of NT-4 and BDNF, but not NGF, was dramatically reduced. These observations demonstrate a selective role for LNR in retrograde transport of the various neurotrophins from distinct target regions in vivo. |
| Document Type: Article |
| Language: English |
| Reprint Address: CURTIS, R (reprint author), REGENERON PHARMACEUT INC, 777 OLD SAW MILL RIVER RD, TARRYTOWN, NY 10591 USA |
Addresses:
1. MEM SLOAN KETTERING CANC CTR, CELLULAR BIOCHEM & BIOPHYS PROGRAM, NEW YORK, NY 10021 USA
2. CORNELL UNIV, SCH MED, DEPT ANAT & CELL BIOL, NEW YORK, NY 10021 USA
3. MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA 02142 USA |
| Publisher: CELL PRESS, 50 CHURCH ST CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Neurosciences |
| IDS Number: RF987 |
| ISSN: 0896-6273 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |