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| NEUROTROPHIN-3 REVERSES EXPERIMENTAL CISPLATIN-INDUCED PERIPHERAL SENSORY NEUROPATHY |
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| Author(s): GAO WQ, DYBDAL N, SHINSKY N, MURNANE A, SCHMELZER C, SIEGEL M, KELLER G, HEFTI F, PHILLIPS HS, WINSLOW JW |
| Source: ANNALS OF NEUROLOGY Volume: 38 Issue: 1 Pages: 30-37 Published: JUL 1995 |
| Times Cited: 114 References: 34 |
| Abstract: Cisplatin, a widely used chemotherapeutic agent, induces a sensory neuropathy with selective loss of vibration sense and proprioception. Here we demonstrate that neurotrophin-3 (NT-3), a member of the nerve growth factor family of neurotrophic factors, restored to normal levels the reduced H-reflex-related sensory nerve conduction velocity induced by cisplatin in rats. NT-3 treatment corrected an abnormal cytoplasmic distribution of neurofilament protein in large sensory neurons in dorsal root ganglia and the reduction in the numbers of myelinated fibers in sural nerves caused by cisplatin. The NT-3-dependent reversal of cisplatin neurotoxicity thus suggests the possible use of NT-3 in the treatment of peripheral sensory neuropathy. |
| Document Type: Article |
| Language: English |
| Reprint Address: GAO, WQ (reprint author), GENENTECH INC, DEPT NEUROSCI, MAIL STOP 71, 460 SAN BRUNO BLVD, S SAN FRANCISCO, CA 94080 USA |
Addresses:
1. GENENTECH INC, DEPT BIOPATHOL & TOXICOL, S SAN FRANCISCO, CA 94080 USA
2. GENENTECH INC, DEPT PROC SCI, S SAN FRANCISCO, CA 94080 USA
3. GENENTECH INC, DEPT METAB & PHARMACOKINET, S SAN FRANCISCO, CA 94080 USA |
| Publisher: LITTLE BROWN CO, 34 BEACON STREET, BOSTON, MA 02108-1493 |
| Subject Category: Clinical Neurology; Neurosciences |
| IDS Number: RH043 |
| ISSN: 0364-5134 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |