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| ROLE OF THE FLT-1 RECEPTOR TYROSINE KINASE IN REGULATING THE ASSEMBLY OF VASCULAR ENDOTHELIUM |
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| Author(s): FONG GH, ROSSANT J, GERTSENSTEIN M, BREITMAN ML |
| Source: NATURE Volume: 376 Issue: 6535 Pages: 66-70 Published: JUL 6 1995 |
| Times Cited: 1,441 References: 27 |
| Abstract: THE vascular endothelial growth factor (VEGF) and its high-affinity binding receptors, the tyrosine kinases Flt-1 and Flk-1, are thought to be important for the development of embryonic vasculature(1-8). Here we report that Flt-1 is essential for the organization of embryonic vasculature, but is not essential for endothelial cell differentiation. Mouse embryos homozygous for a targeted mutation in the flt-1 locus, flt-1(lcz), formed endothelial cells in both embryonic and extra-embryonic regions, but assembled these cells into abnormal vascular channels and died in utero at mid-somite stages. At earlier stages, the blood islands of flt-1(lcz) homozygotes were abnormal, with angioblasts in the interior as well as on the periphery. We suggest that the Flt-1 signalling pathway may regulate normal endothelial cell-cell or cell-matrix interactions during vascular development. |
| Document Type: Article |
| Language: English |
Addresses:
1. MT SINAI HOSP, SAMUEL LUNENFELD RES INST, TORONTO, ON M5G 1X5 CANADA
2. UNIV TORONTO, DEPT MOLEC & MED GENET, TORONTO, ON M5S 1A8 CANADA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: RH111 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |