| TURNING DOWN THE HEAT - NEW ROUTES TO INHIBITION OF INFLAMMATORY SIGNALING BY PROSTAGLANDIN H-2 SYNTHASES |
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| Author(s): MUNROE DG, LAU CY |
| Source: CHEMISTRY & BIOLOGY Volume: 2 Issue: 6 Pages: 343-350 Published: JUN 1995 |
| Times Cited: 17 References: 33 |
| Abstract: Many nonsteroidal anti-inflammatory drugs act by inhibiting the cyclooxygenase activity oi prostaglandin H-2 synthase (PGHS), a key enzyme in the biosynthesis of prostaglandins. Gastric toxicity remains a serious problem with the current drugs, however. Recent advances in the understanding of PGHS now suggest two possible approaches to producing drugs with fewer side effects. |
| Document Type: Article |
| Language: English |
| Reprint Address: MUNROE, DG (reprint author), RW JOHNSON PHARMACEUT RES INST, 19 GREEN BELT DR, DON MILLS, ON M3C 1L9 CANADA |
| Publisher: CURRENT BIOLOGY LTD, 34-42 CLEVELAND STREET, LONDON, ENGLAND W1P 6LB |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: RH722 |
| ISSN: 1074-5521 |