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| DISRUPTION OF THE ARCHITECTURAL FACTOR HMGI-C - DNA-BINDING AT HOOK MOTIFS FUSED IN LIPOMAS TO DISTINCT TRANSCRIPTIONAL REGULATORY DOMAINS |
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| Author(s): ASHAR HR, FEJZO MS, TKACHENKO A, ZHOU X, FLETCHER JA, WEREMOWICZ S, MORTON CC, CHADA K |
| Source: CELL Volume: 82 Issue: 1 Pages: 57-65 Published: JUL 14 1995 |
| Times Cited: 307 References: 69 |
| Abstract: Lipomas are one of the most common mesenchymal neoplasms in humans. They are characterized by consistent cytogenetic aberrations involving chromosome 12 in bands q14-15. Interestingly, this region is also the site of rearrangement for other mesenchymally derived tumors. This study demonstrates that HMGI-C, an architectural factor that functions in transcriptional regulation, has been disrupted by rearrangement at the 12q14-15 chromosomal breakpoint in lipomas. Chimeric transcripts were isolated from two lipomas in which HMGI-C DNA-binding domains (AT hook motifs) are fused to either a LIM or an acidic transactivation domain. These results, identifying a gene rearranged in a benign neoplastic process that does not proceed to a malignancy, suggest a role for HMGI-C in adipogenesis and mesenchyme differentiation. |
| Document Type: Article |
| Language: English |
| Reprint Address: ASHAR, HR (reprint author), UNIV MED & DENT NEW JERSEY, ROBERT WOOD JOHNSON MED SCH, DEPT BIOCHEM, PISCATAWAY, NJ 08854 USA |
Addresses:
1. HARVARD UNIV, SCH MED, DEPT GENET, BOSTON, MA 02115 USA
2. HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02115 USA
3. HARVARD UNIV, SCH MED, DEPT PEDIAT, BOSTON, MA 02115 USA
4. HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DIV PEDIAT ONCOL, BOSTON, MA 02115 USA
5. HARVARD UNIV, BRIGHAM & WOMENS HOSP, SCH MED, DEPT PATHOL, BOSTON, MA 02115 USA |
| Publisher: CELL PRESS, 50 CHURCH ST CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: RK424 |
| ISSN: 0092-8674 |
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