| HBD-1 - A NOVEL BETA-DEFENSIN FROM HUMAN PLASMA |
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| Author(s): BENSCH KW, RAIDA M, MAGERT HJ, SCHULZKNAPPE P, FORSSMANN WG |
| Source: FEBS LETTERS Volume: 368 Issue: 2 Pages: 331-335 Published: JUL 17 1995 |
| Times Cited: 326 References: 19 |
| Abstract: We report the isolation and characterization of a novel peptide with significant sequence homology to beta-defensins from human blood filtrate. The human beta-defensin-1 (hBD-1) is a short basic peptide of 36 amino acid residues, It contains six cysteines forming three intramolecular disulfide bonds. The molecular mass of hBD-1 is 3928.6 Da. Cloning of the specific cDNA confirmed the amino acid sequence of the native peptide, hBD-1 shares the nine conserved amino acids characteristic for beta-defensins from respiratory epithelial cells and neutrophils of cattle and chicken leukocytes. hBD-1 is present in nanomolar concentration in human plasma. |
| Document Type: Article |
| Language: English |
| Reprint Address: BENSCH, KW (reprint author), NIEDERSACHS INST PEPTID FORSCH, FEODOR LYNEN STR 31, D-30625 HANNOVER, GERMANY |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| IDS Number: RK684 |
| ISSN: 0014-5793 |