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| WEIGHT-REDUCING EFFECTS OF THE PLASMA-PROTEIN ENCODED BY THE OBESE GENE |
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| Author(s): HALAAS JL, GAJIWALA KS, MAFFEI M, COHEN SL, CHAIT BT, RABINOWITZ D, LALLONE RL, BURLEY SK, FRIEDMAN JM |
| Source: SCIENCE Volume: 269 Issue: 5223 Pages: 543-546 Published: JUL 28 1995 |
| Times Cited: 2,702 References: 15 |
| Abstract: The gene product of the ob locus is important in the regulation of body weight. The ob product was shown to be present as a 16-kilodalton protein in mouse and human plasma but was undetectable in plasma from C57BL/6J ob/ob mice. Plasma levels of this protein were increased in diabetic (db) mice, a mutant thought to be resistant to the effects of ab. Daily intraperitoneal injections of either mouse or human recombinant OB protein reduced the body weight of ob/ob mice by 30 percent after 2 weeks of treatment with no apparent toxicity but had no effect on db/db mice. The protein reduced food intake and increased energy expenditure in ob/ob mice. Injections of wild-type mice twice daily with the mouse protein resulted in a sustained 12 percent weight loss, decreased food intake, and a reduction of body fat from 12.2 to 0.7 percent. These data suggest that the OB protein serves an endocrine function to regulate body fat stores. |
| Document Type: Article |
| Language: English |
Addresses:
1. ROCKEFELLER UNIV, HOWARD HUGHES MED INST, GENET MOLEC LAB, NEW YORK, NY 10021 USA
2. ROCKEFELLER UNIV, HOWARD HUGHES MED INST, MOLEC BIOPHYS LABS, NEW YORK, NY 10021 USA
3. ROCKEFELLER UNIV, MASS SPECTROMETRY LAB, NEW YORK, NY 10021 USA
4. COLUMBIA UNIV, DEPT STAT, NEW YORK, NY 10027 USA
5. BROOKWOOD BIOMED CTR, BIRMINGHAM, AL 35209 USA |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: RL495 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |