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| DISTINCT GENETIC-LOCI CONTROL DEVELOPMENT OF BENIGN AND MALIGNANT SKIN TUMORS IN MICE |
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| Author(s): NAGASE H, BRYSON S, CORDELL H, KEMP CJ, FEE F, BALMAIN A |
| Source: NATURE GENETICS Volume: 10 Issue: 4 Pages: 424-429 Published: AUG 1995 |
| Times Cited: 80 References: 46 |
| Abstract: Genetic susceptibility to chemically induced skin cancer in mice is controlled by multiple unlinked genetic loci. Mus spretus mice have dominant resistance genes which confer resistance to interspecific F-1 hybrids with susceptible Mus musculus strains. We have mapped three major resistance loci using a combination of Mapmaker/QTL analysis and multiple regression analysis to mouse chromosomes 5 and 7. At least two independent loci on chromosome 7 exert their effects primarily during benign tumour development and have very little influence on tumour progression. On the other hand, probably a single locus on chromosome 5 affects both early and late stages of malignancy. The results indicate that benign and malignant tumours are largely under independent genetic control. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV GLASGOW, DEPT MED ONCOL, CRC, BEATSON LABS, GLASGOW, LANARK SCOTLAND
2. BEATSON INST CANC RES, GLASGOW G61 1BD, LANARK SCOTLAND
3. UNIV OXFORD, WELLCOME TRUST CTR HUMAN GENET, NUFFIELD DEPT SURG, OXFORD OX3 7BN, ENGLAND
4. FRED HUTCHINSON CANC RES CTR, SEATTLE, WA 98104 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: RM375 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |