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| PHASE-II TRIAL OF I-131 B1 (ANTI-CD20) ANTIBODY THERAPY WITH AUTOLOGOUS STEM-CELL TRANSPLANTATION FOR RELAPSED B-CELL LYMPHOMAS |
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| Author(s): PRESS OW, EARY JF, APPELBAUM FR, MARTIN PJ, NELP WB, GLENN S, FISHER DR, PORTER B, MATTHEWS DC, GOOLEY T, BERNSTEIN ID |
| Source: LANCET Volume: 346 Issue: 8971 Pages: 336-340 Published: AUG 5 1995 |
| Times Cited: 360 References: 35 |
| Abstract: 25 patients with relapsed B-cell lymphomas were evaluated with trace-labelled doses (2.5 mg/kg, 185-370 MBq [5-10 mCi]) of I-131-labelled anti-CD20 (B1) antibody in a phase II trial. 22 patients achieved I-131-B1 biodistributions delivering higher doses of radiation to tumour sites than to normal organs and 21 of these were treated with therapeutic infusions of I-131-B1 (12.765-29.045 GBq) followed by autologous haemopoietic stem cell reinfusion. 18 of the 21 treated patients had objective responses, including 16 complete remissions. One patient died of progressive lymphoma and one died of sepsis. Analysis of our phase I and II trials with I-131-labelled B1 reveal a progression-free survival of 62% and an overall survival of 93% with a median follow-up of 2 years. I-131-anti-CD20 (B1) antibody therapy produces complete responses of long duration in most patients with relapsed B-cell lymphomas when given at maximally tolerated doses with autologous stem cell rescue. |
| Document Type: Article |
| Language: English |
| Reprint Address: PRESS, OW (reprint author), UNIV WASHINGTON, CTR CANC, DEPT MED, MAILSTOP RC08, SEATTLE, WA 98195 USA |
Addresses:
1. UNIV WASHINGTON, DEPT PEDIAT, SEATTLE, WA 98195 USA
2. UNIV WASHINGTON, DEPT RADIOL, SEATTLE, WA 98195 USA
3. UNIV WASHINGTON, DEPT BIOL STRUCT, SEATTLE, WA 98195 USA
4. UNIV WASHINGTON, DEPT BIOSTAT, SEATTLE, WA 98195 USA
5. FRED HUTCHINSON CANC RES CTR, SEATTLE, WA USA
6. COULTER CORP, SEATTLE, WA USA
7. FIRST HILL DIAGNOST IMAGING, SEATTLE, WA USA
8. PACIFIC NW LAB, RICHLAND, WA 99352 USA |
| Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL |
| Subject Category: Medicine, General & Internal |
| IDS Number: RM713 |
| ISSN: 0099-5355 |
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