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| GENETIC INSTABILITY OCCURS IN THE MAJORITY OF YOUNG-PATIENTS WITH COLORECTAL-CANCER |
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| Author(s): LIU B, FARRINGTON SM, PETERSEN GM, HAMILTON SR, PARSONS R, PAPADOPOULOS N, FUJIWARA T, JEN J, KINZLER KW, WYLLIE AH, VOGELSTEN B, DUNLOP MG |
| Source: NATURE MEDICINE Volume: 1 Issue: 4 Pages: 348-352 Published: APR 1995 |
| Times Cited: 271 References: 39 |
| Abstract: Replication errors (RER) associated with genetic instability have been found in cancers of several different types and particularly in the tumours of patients with hereditary non-polyposis colorectal cancer (HNPCC). We have here determined the prevalence of such instability in relation to age among patients without HNPCC. Colorectal cancers (CRCs) in the majority of patients 35 years of age or younger exhibited instability (58% of 31 patients), whereas CRCs from patients older than 35 uncommonly did (12% of 158, P < 0.0001). Twelve of the patients under 35 with instability were evaluated for alterations of mismatch repair genes, and five were found to harbour germline mutations. These data suggest that the mechanisms underlying tumour development in young CRC patients differ from those in most order patients, regardless of HNPCC status. The results have important implications for genetic testing and management of young CRC patients and their families. |
| Document Type: Article |
| Language: English |
| Reprint Address: LIU, B (reprint author), JOHNS HOPKINS ONCOL CTR, 424 N BOND ST, BALTIMORE, MD 21231 USA |
Addresses:
1. WESTERN GEN HOSP, MRC, HUMAN GENET UNIT, EDINBURGH EH4 2XU, MIDLOTHIAN SCOTLAND
2. JOHNS HOPKINS UNIV, SCH HYG & PUBL HLTH, BALTIMORE, MD 21205 USA
3. JOHNS HOPKINS UNIV, DEPT PATHOL, BALTIMORE, MD 21205 USA
4. JOHNS HOPKINS UNIV, DEPT ONCOL, BALTIMORE, MD 21205 USA
5. UNIV EDINBURGH, SCH MED, DEPT PATHOL, CANC RES CAMPAIGN LABS, EDINBURGH EH8 9AG, MIDLOTHIAN SCOTLAND
6. UNIV EDINBURGH, ROYAL INFIRM, DEPT SURG, EDINBURGH EH3 9YW, MIDLOTHIAN SCOTLAND |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: RN098 |
| ISSN: 1078-8956 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |