| | |  | | | | Record from Web of Science® | | | | | | |
| CLINICAL ISSUES IN ANTIBODY DESIGN |
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| Author(s): CHESTER KA, HAWKINS RE |
| Source: TRENDS IN BIOTECHNOLOGY Volume: 13 Issue: 8 Pages: 294-300 Published: AUG 1995 |
| Times Cited: 52 References: 54 |
| Abstract: Antibody genes can now be cloned and expressed in various ways to give new versions of antibodies that possess reduced immunogenicity, improved affinity, altered size, increased avidity and novel effector functions. The task for any clinical application is, first, to define a relevant target, and then to design the optimal antibody-based therapeutic molecule to react with that target. This article reviews these improved antibody-based molecules and examines their role in cancer therapy. |
| Document Type: Article |
| Language: English |
| Reprint Address: CHESTER, KA (reprint author), ROYAL FREE HOSP, SCH MED, DEPT CLIN ONCOL, ROWLAND HILL ST, LONDON NW3 2PF, ENGLAND |
Addresses:
1. MRC CTR, DEPT ONCOL, CAMBRIDGE CB2 2HQ, ENGLAND |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Biotechnology & Applied Microbiology |
| IDS Number: RN506 |
| ISSN: 0167-7799 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |