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| ANGIOTENSIN-CONVERTING ENZYME POLYMORPHISM AND DEVELOPMENT OF DIABETIC NEPHROPATHY IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS |
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| Author(s): MIZUIRI S, HEMMI H, INOUE A, YOSHIKAWA H, TANEGASHIMA M, FUSHIMI T, ISHIGAMI M, AMAGASAKI Y, OHARA T, SHIMATAKE H, HASEGAWA A |
| Source: NEPHRON Volume: 70 Issue: 4 Pages: 455-459 Published: AUG 1995 |
| Times Cited: 61 References: 27 |
| Abstract: We determined the distribution frequency of angiotensin-converting enzyme insertion/deletion (I/D) polymorphism in 111 Japanese patients with noninsulin-dependent diabetes mellitus (NIDDM) of at least 10 years duration (80 patients with diabetic nephropathy and 31 patients without nephropathy) and 76 healthy Japanese controls. Patients with diabetic nephropathy showed an excess of the ID genotype compared with patients without nephropathy (p < 0.02) and less of the II genotype compared with healthy controls (p < 0.01) and patients without nephropathy (p < 0.01). NIDDM patients with the II genotype have a decreased risk for the development of diabetic nephropathy. |
| Document Type: Article |
| Language: English |
| Reprint Address: MIZUIRI, S (reprint author), TOHO UNIV, SCH MED, DEPT NEPHROL, OHTA KU, 6-11-1 OHMORI NISHI, TOKYO 143, JAPAN |
Addresses:
1. TOHO UNIV, SCH MED, DEPT MOLEC BIOL, TOKYO 143, JAPAN |
| Publisher: KARGER, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND |
| Subject Category: Urology & Nephrology |
| IDS Number: RN536 |
| ISSN: 0028-2766 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |