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| HIGH-LEVELS OF ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) MEMORY CYTOTOXIC T-LYMPHOCYTE ACTIVITY AND LOW VIRAL LOAD ARE ASSOCIATED WITH LACK OF DISEASE IN HIV-1-INFECTED LONG-TERM NONPROGRESSORS |
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| Author(s): RINALDO C, HUANG XL, FAN Z, DING M, BELTZ L, LOGAR A, PANICALI D, MAZZARA G, LIEBMANN J, COTTRILI M, GUPTA P |
| Source: JOURNAL OF VIROLOGY Volume: 69 Issue: 9 Pages: 5838-5842 Published: SEP 1995 |
| Times Cited: 428 References: 42 |
| Abstract: Lack of disease in long-term nonprogressors with human immuodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8(+) memory cytotoxic T lymphocytes specific for Gag, Pol, and Env, compared with level present in intermediate and advanced progressors. CD8(+) memory cytotoxic T lymphocytes may have an important role in controlling HIV-1 replication and preventing disease in long-term nonprogressors. |
| Document Type: Note |
| Language: English |
Addresses:
1. UNIV PITTSBURGH, SCH MED, DEPT PATHOL, PITTSBURGH, PA 15213 USA
2. UNIV PITTSBURGH, SCH MED, DEPT INFECT DIS & MICROBIOL, PITTSBURGH, PA 15213 USA
3. UNIV PITTSBURGH, GRAD SCH PUBL HLTH, PITTSBURGH, PA 15213 USA
4. THERION BIOL, CAMBRIDGE, MA 02142 USA |
| Publisher: AMER SOC MICROBIOLOGY, 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 |
| Subject Category: Virology |
| IDS Number: RN986 |
| ISSN: 0022-538X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |