| | |  | | | | Record from Web of Science® | | | | | | |
| THE EMERGENCE OF A HIGHLY TRANSMISSIBLE LINEAGE OF CBL(+) PSEUDOMONAS (BURKHOLDERIA) CEPACIA CAUSING CF CENTER EPIDEMICS IN NORTH-AMERICA AND BRITAIN |
|
|
| Author(s): SUN L, JIANG RZ, STEINBACH S, HOLMES A, CAMPANELLI C, FORSTNER J, SAJJAN U, TAN Y, RILEY M, GOLDSTEIN R |
| Source: NATURE MEDICINE Volume: 1 Issue: 7 Pages: 661-666 Published: JUL 1995 |
| Times Cited: 154 References: 27 |
| Abstract: The rapid increase in Pseudomonas (Burkholderia) cepacia infection in cystic fibrosis (CF) patients suggests epidemic transmission, but the degree of transmissibility remains controversial as conflicting conclusions have been drawn from studies at different CF centres. This report provides the first DNA sequence-based documentation of a divergent evolutionary lineage of P. cepacia associated with CF centre epidemics in North America (Toronto) and Europe (Edinburgh). The involved epidemic clone encoded and expressed novel cable (Cbl) pill that bind to CF mucin. The sequence of the cblA pilin subunit gene carried by the epidemic isolates proved to be invariant. Although it remains to be determined how many distinct, highly transmissible lineages exist, our results provide both a DNA sequence and chromosomal fingerprint that can be used to screen for one such particularly infectious, transatlantic clone. |
| Document Type: Article |
| Language: English |
Addresses:
1. BOSTON UNIV, SCH MED, MAXWELL FINLAND LAB INFECT DIS, MOLEC GENET SECT, BOSTON, MA 02118 USA
2. BOSTON CITY HOSP, BOSTON, MA 02118 USA
3. BOSTON UNIV, SCH MED, DEPT PEDIAT, BOSTON, MA 02118 USA
4. HOSP SICK CHILDREN, DIV BIOCHEM, RES INST, TORONTO, ON M5G 1X8 CANADA
5. YALE UNIV, DEPT BIOL, NEW HAVEN, CT 06511 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: RQ066 |
| ISSN: 1078-8956 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |