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| SERUM P53 ANTIBODIES AS EARLY MARKERS OF LUNG-CANCER |
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| Author(s): LUBIN R, ZALCMAN G, BOUCHET L, TREDANIEL J, LEGROS Y, CAZALS D, HIRSCH A, SOUSSI T |
| Source: NATURE MEDICINE Volume: 1 Issue: 7 Pages: 701-702 Published: JUL 1995 |
| Times Cited: 195 References: 13 |
| Abstract: The p53 alteration is the most common alteration found in human cancer. It usually involves missense mutations that stabilize the p53 protein, which in turn accumulates, reaching levels detectable by immunohistochemistry. We(1-4) and others(5-8) have demonstrated that this overexpression of mutant p53 protein can induce a specific humoral response in cancer patients. This result was assessed by the presence of p53 antibodies in sera of patients with various types of cancers, whereas normal populations do not exhibit such antibodies. In lung cancer, the prevalence of p53 antibodies is high (30%) and is correlated with a very high rate of p53 mutations in this cancer (60-70%)(2,8). We show that these antibodies are always present at the time of diagnosis, but never appear during tumour development, an observation strengthened by the fact that these antibodies are mostly IgG, corresponding to a secondary immune response. These results suggest that the humoral response is an early event and that p53 antibodies can be used as a precocious marker of p53 alteration before clinical manifestation of the disease. |
| Document Type: Article |
| Language: English |
Addresses:
1. INST GENET MOLEC, INSERM, U301, F-75010 PARIS, FRANCE
2. HOP ST LOUIS, SERV PNEUMOL, F-75010 PARIS, FRANCE
3. HOP ST LOUIS, ANATOMOPATHOL LAB, F-75010 PARIS, FRANCE |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: RQ066 |
| ISSN: 1078-8956 |
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