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| ENERGY-COUPLED TRANSPORT AND SIGNAL-TRANSDUCTION THROUGH THE GRAM-NEGATIVE OUTER-MEMBRANE VIA TONB-EXBB-EXBD-DEPENDENT RECEPTOR PROTEINS |
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| Author(s): BRAUN V |
| Source: FEMS MICROBIOLOGY REVIEWS Volume: 16 Issue: 4 Pages: 295-307 Published: JUL 1995 |
| Times Cited: 212 References: 64 |
| Abstract: Iron in,the form of ferric siderophore complexes and vitamin B-12 are transported through the outer membrane of Gram-negative bacteria by a mechanism which consumes energy. There is no known energy source in the outer membrane or in the adjacent periplasmic space so that energy is provided by the electrochemical potential across the cytoplasmic membrane. Energy flows from the cytoplasmic into the outer membrane via a complex consisting of the TonB, ExbB and ExbD proteins which are anchored in the cytoplasmic membrane. It is proposed that the TonB-ExbB-ExbD complex opens - via an energized conformation of the TonB protein - channels in the outer membrane, formed by proteins which serve as highly specific binding sites for the various ferric siderophores and vitamin B-12. In addition, outer membrane receptors together with the TonB-ExbB-ExbD complex are directly involved in induction of the transcription of ferric citrate and pseudobactin transport genes of Escherichia coli and Pseudomonas putida, respectively. |
| Document Type: Review |
| Language: English |
| Reprint Address: BRAUN, V (reprint author), UNIV TUBINGEN, MORGENSTELLE 28, D-72076 TUBINGEN, GERMANY |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Microbiology |
| IDS Number: RQ145 |
| ISSN: 0168-6445 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |