| | |  | | | | Record from Web of Science® | | | | | | |
| LINKAGE ANALYSES OF CHROMOSOME-18 MARKERS DO NOT IDENTIFY A MAJOR SUSCEPTIBILITY LOCUS FOR BIPOLAR AFFECTIVE-DISORDER IN THE OLD-ORDER AMISH |
|
|
| Author(s): PAULS DL, OTT J, PAUL SM, ALLEN CR, FANN CSJ, CARULLI JP, FALLS KM, BOUTHILLIER CA, GRAVIUS TC, KEITH TP, EGELAND JA, GINNS EI |
| Source: AMERICAN JOURNAL OF HUMAN GENETICS Volume: 57 Issue: 3 Pages: 636-643 Published: SEP 1995 |
| Times Cited: 43 References: 39 |
| Abstract: Previously reported linkage of bipolar affective disorder to DNA markers in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D18S21, D18S53, D18S44, and D18S40) were examined in three kindreds containing 31 bipolar I (BP I) individuals. Although linkage findings were replicated in the one previously studied Amish pedigree containing four BP I individuals, linkage to this region was excluded in the larger sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this population. |
| Document Type: Article |
| Language: English |
| Reprint Address: PAULS, DL (reprint author), YALE UNIV, SCH MED, CTR CHILD STUDY, 230 S FRONTAGE RD, NEW HAVEN, CT 06510 USA |
Addresses:
1. NEW YORK STATE PSYCHIAT INST & HOSP, NEW YORK, NY USA
2. COLUMBIA UNIV, NEW YORK, NY USA
3. NIMH, IRP, CLIN NEUROSCI BRANCH, BETHESDA, MD 20892 USA
4. ELI LILLY & CO, LILLY RES LABS, INDIANAPOLIS, IN 46285 USA
5. UNIV MIAMI, DEPT PSYCHIAT, MIAMI, FL 33152 USA
6. GENOME THERAPEUT CORP, WALTHAM, MA USA |
| Publisher: UNIV CHICAGO PRESS, 5720 S WOODLAWN AVE, CHICAGO, IL 60637 |
| Subject Category: Genetics & Heredity |
| IDS Number: RR605 |
| ISSN: 0002-9297 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |