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| LOSS OF HETEROZYGOSITY AT CHROMOSOME-11 IN BREAST-CANCER - ASSOCIATION OF PROGNOSTIC FACTORS WITH GENETIC ALTERATIONS |
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| Author(s): GUDMUNDSSON J, BARKARDOTTIR RB, EIRIKSDOTTIR G, BALDURSSON T, ARASON A, EGILSSON V, INGVARSSON S |
| Source: BRITISH JOURNAL OF CANCER Volume: 72 Issue: 3 Pages: 696-701 Published: SEP 1995 |
| Times Cited: 70 References: 38 |
| Abstract: We examined DNA from 116 female and four male breast cancer patients for loss of heterozygosity (LOH). DNA was analysed by polymerase chain reaction using ten microsatellite markers on chromosome ii. Three distinct regions of LOH were identified: 11p15.5, 11q13 and 11q22-qter with a LOH frequency of 19, 23 and 37-43% respectively. The marker D11S969 showing the highest frequency of LOH (43%) is located at the 11q24.1-q25 region. No previous molecular genetic studies have shown frequent LOH at the region telomeric to q23 on chromosome 11. Southern analysis revealed that LOH at 11q13 was due to amplification, whereas LOH at 11q22-qter was due to deletion. LOH at 11p15.5 was associated with paucity of hormone receptor proteins, high S-phase and positive node status. An association was found between LOH at 11q13 and positive node status. LOH at the 11q22-qter region correlated with a high S-phase fraction. A significant association was found between LOH at 11p15 and chromosome regions 17q21 (the BRCAl region) and 3p. |
| Document Type: Article |
| Language: English |
| Reprint Address: GUDMUNDSSON, J (reprint author), UNIV ICELAND, DEPT PATHOL, DIV CELL BIOL, BOX 1465, IS-121 REYKJAVIK, ICELAND |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HANTS, ENGLAND RG21 2XS |
| Subject Category: Oncology |
| IDS Number: RT006 |
| ISSN: 0007-0920 |
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