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| MICROALLELOTYPING DEFINES THE SEQUENCE AND TEMPO OF ALLELIC LOSSES AT TUMOR-SUPPRESSOR GENE LOCI DURING COLORECTAL-CANCER PROGRESSION |
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| Author(s): BOLAND CR, SATO J, APPELMAN HD, BRESALIER RS, FEINBERG AP |
| Source: NATURE MEDICINE Volume: 1 Issue: 9 Pages: 902-909 Published: SEP 1995 |
| Times Cited: 148 References: 48 |
| Abstract: Microallelotyping of many regions from individual colorectal tumours was used to determine the sequence and tempo of allelic loss on 5q, 17p and 18q during neoplastic progression. No allelic losses were found in normal tissues surrounding colorectal neoplasms, but losses occurred abruptly on 5q at the transition from normal colonic epithelium to the benign adenoma, and on 17p at the transition from adenoma to carcinoma, indicating an essential role for these losses in tumour progression. Allelic losses were uniform throughout extensively microdissected benign adenomas and carcinomas. However, substantial allelic heterogeneity was found in high-grade dysplasia, the transition lesion between adenoma and carcinoma. Thus, allelic losses on 5q and 17p are associated with abrupt waves of clonal neoplastic expansion, and high-grade dysplasia is characterized by a high degree of allelic heterogeneity. |
| Document Type: Article |
| Language: English |
| Reprint Address: BOLAND, CR (reprint author), VET AFFAIRS MED CTR, DEPT INTERNAL MED, 4410 KRESGE 3, 200 ZINA PITCHE PL, ANN ARBOR, MI 48109 USA |
Addresses:
1. UNIV MICHIGAN, CTR CANC, ANN ARBOR, MI 48109 USA
2. UNIV TSUKUBA, INST CLIN MED, TSUKUBA, IBARAKI 305 JAPAN
3. UNIV MICHIGAN HOSP, MED CTR, DEPT PATHOL, ANN ARBOR, MI 48109 USA
4. HENRY FORD HOSP, DETROIT, MI 48202 USA
5. JOHNS HOPKINS UNIV, SCH MED, DEPT INTERNAL MED, BALTIMORE, MD 20105 USA
6. JOHNS HOPKINS UNIV, SCH MED, DEPT HUMAN GENET, BALTIMORE, MD 20105 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: RT303 |
| ISSN: 1078-8956 |
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