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| MORTALITY BEFORE AND AFTER HIV-INFECTION IN THE COMPLETE UK POPULATION OF HEMOPHILIACS |
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| Author(s): DARBY SC, EWART DW, GIANGRANDE PLF, DOLIN PJ, SPOONER RJD, RIZZA CR |
| Source: NATURE Volume: 377 Issue: 6544 Pages: 79-82 Published: SEP 7 1995 |
| Times Cited: 86 References: 24 |
| Abstract: DURING 1977-91, 6,278 males diagnosed with haemophilia were living in the UK. During 1979-86, 1,227 were infected with the human immunodeficiency virus (HIV-1) as a result of transfusion therapy (median estimated seroconversion date, October 1982). Among 2,448 with severe haemophilia, the annual death rate was stable at 8 per 1,000 during 1977-84; during 1985-92 death rates remained at 8 per 1,000 among HIV-seronegative patients but rose steeply in seropositive patients, reaching 81 per 1,000 in 1991-92. Among 3,830 with mild or moderate haemophilia, the pattern was similar, with an initial death rate of 4 per 1,000 in 1977-84, rising to 85 per 1,000 in 1991-92 in seropositive patients. During 1985-92, there were 403 deaths in HIV seropositive patients, whereas 60 would have been predicted from rates in seronegatives, suggesting that 85% of the deaths in seropositive patients were due to HIV infection. Most of the excess deaths were certified as due to AIDS or to conditions recognized as being associated with AIDS. |
| Document Type: Article |
| Language: English |
| Reprint Address: DARBY, SC (reprint author), UNIV OXFORD, RADCLIFFE INFIRM, IMPERIAL CANC RES FUND, EPIDEMIOL UNIT, GIBSON BLDG, OXFORD OX2 6HE, ENGLAND |
Addresses:
1. CHURCHILL HOSP, OXFORD HAEMOPHILIA CTR, OXFORD OX3 7LJ, ENGLAND |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: RT725 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |